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Cryo-electron microscopy (cryoEM) is revolutionizing the biosciences by enabling the imaging of macromolecules, viruses, and cellular substructures at near-atomic to atomic resolutions. Advances in detectors, computation, and EM design now produce high-resolution images of rapidly frozen samples that disruptively surpass current methods (e.g., X-ray crystallography) because they require far less material, capture natural states, do not require crystallization, and enable time-resolved imaging.

A cross-campus initiative led by a coalition of partners including the Department of Biochemistry, the School of Medicine and Public Health, the Morgridge Institute for Research, the UW Carbone Cancer Center, the Office of the Vice Chancellor for Research and Graduate Education, and the College of Engineering Material Science Center is working on multiple fronts to keep UW-Madison at the forefront of bioscience research enabled by CryoEM. These efforts now include: